Genome-wide association study (GWAS) has been a great success in the past decade, with tens of thousands of loci identified associated with many complex diseases in humans. However, challenges still remain in both identifying new risk loci and interpreting results. Bonferroni-corrected significance level is a conservative threshold for high dimensional hypothesis testing, leading to insufficient statistical power when the effect size is moderate at each risk locus. Complex structure of linkage disequilibrium also makes it challenging to distinguish causal variants from large haplotype blocks. We propose GenoWAP (Genome-Wide Association Prioritizer), a post-GWAS prioritization method that integrates genomic functional annotation and GWAS test statistics. After prioritization, real disease-associated loci become easier to be identified. Within each locus, GenoWAP is also able to identify real functional spots among correlated markers. GenoWAP has the potential to be widely used to reveal functional spots at disease-associated risk loci and guide further studies such as resequencing analysis.
The GenoWAP paper will be submitted soon. The website is now officially online at genocanyon.med.yale.edu/GenoWAP. Feel free to check out the software and let us know what you think.